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RNA interference experiments confirmed PDE1A and to a smaller extent PDE1C as molecular targets accounting for the protective efficacy.
We screened 1,600 FDA-approved drugs for their efficacy to protect LUHMES cells from degeneration induced by wild-type α-synuclein and identified dipyridamole, a non-selective phosphodiesterase inhibitor, as top hit.
Systematic analysis of other phosphodiesterase inhibitors identified a specific phosphodiesterase 1 inhibitor as most potent to rescue from α-synuclein toxicity.
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New Public Emergency Communications Network ''National SOS'' to Conduct Statewide Connecticut Emergency Preparedness Drill on June 17th.; Drill to Involve All Connecticut Citizens, Plus Special Test of a Hartford-Area Receiving Station Radio Network plan, ham radio operators would rapidly relay the public's emergency needs to local and state authorities -- such as police and fire departments -- as well as to national rescue and relief agencies.